Summary
Fentanyl (also known as Fentanil and by the brand names Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis, Instanyl, Abstral, Lazanda among others) is a potent opioid substance of the anilidopiperidine class. It is a strong agonist at the μ-opioid receptors and approximately 40 to 50 times more potent than pharmaceutical grade (i.e. 100% pure) heroin and roughly 80 to 100 times more potent than morphine.[citation needed].
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-25μg | 25-50μg | 50-75μg | 75ug+ |
| Transdermal | 12-25μg | 25-50μg | 50-100μg | 100μg+ |
| Sublingual | 10-25μg | 25-50μg | 50-75μg | 75μg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | - | - | - |
| Insufflated | 15-30 min | - | - | 60-0 min |
| Intravenous | 1 min | - | 1-2 hrs | - |
| Transdermal | 2-4 hrs | 12-24 hrs | 12-24 hrs | 2880-0 min |
| Sublingual | 12-30 min | - | - | 60-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Pain Relief
- Physical Euphoria
- Cough Suppression
- Analgesia
Negative
- Respiratory Depression
- Nausea
- Increased Perspiration
- Dry mouth
- Sweating
- Fatigue
- Sedation
- Pupil Constriction
- Difficulty Urinating
- Sedative effects
- Somnolence
- Weakness
- Itchiness
Positive
- Cognitive Euphoria
- Anxiety Suppression
- Dream Potentiation
- Euphoria
- Feelings of relaxation
Negative
- Constipation
- Compulsive Redosing
- Drowsiness
- Confusion
- Dizziness
- Anxiety
- Changes in focus
- Attention
Positive
Negative
- Appetite Suppression
- Decreased Libido
- Double Vision
- Dehydration
- Orgasm Suppression
- Orgasm depression
- Acuity Suppression
- Disinhibition
- Light sensitivity
- Dulled perception