Hydrocodone - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

Hydrocodone is most commonly prescribed in combination with acetaminophen (Vicodin, Norco, Lortab). When used recreationally or in high doses, the acetaminophen component poses serious risk of liver damage or failure. Respiratory depression is the primary cause of fatal overdose, particularly when combined with other CNS depressants.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	5-10mg	10-25mg	25-40mg	40mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	10-30 min	30-60 min	1-2 hrs	2-4 hrs	12-12 hrs	3.7-7.5 hrs

Opioid MME Calculator

⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.

Convert from

mg

Convert to

10 mg Hydrocodone

≈

— mg Morphine

⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

Effect Profile

307 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 266 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 8.0

Intense 8/10

Strong euphoria, itching/nausea, pain relief, and sedation

Euphoria / Warmth ×3

10

physical euphoria cognitive euphoria euphoria mood lift

Analgesia ×2

9

pain relief analgesia

Sedation / Relaxation ×1

8

sedation dream potentiation

⚠ Itching / Nausea ×1

10

nausea constipation dry mouth

Based on reports from:

Erowid Experience Reports PsychonautWiki Hydrocodone

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Cross-Tolerances

Other opioids (e.g., morphine, oxycodone, codeine)

70%

Effects Erowid Bluelight

Aggregated from 266 Erowid and 41 Bluelight experience reports

Positive Effects 43

Euphoria 47.2% 89%

Contentment 41.5% 84%

Sedation 35.2% 86%

Anxiety Suppression 27.7% 82%

Stimulation 25.9% 70%

Sociability Enhancement 24.4% 84%

Thought Deceleration 22.0% 78%

Music Enhancement 21.2% 85%

Empathy 21.2% 80%

Hot Flashes 19.5% 82%

Drowsiness 19.5% 90%

Tingling 17.1% 85%

Body High 16.0% 88%

Vivid Dreams 14.6% 82%

Tactile Enhancement 13.1% 85%

Focus Enhancement 12.4% 80%

Color Enhancement 10.5% 70%

Numbness 9.8% 85%

Heaviness 9.8% 81%

Lightness 7.3% 77%

Adverse Effects 32

Nausea 29.0% 83%

Dizziness 22.0% 84%

Vomiting 19.5% 90%

Itching 19.5% 84%

Confusion 12.7% 85%

Stomach Cramps 12.2% 77%

Headache 11.4% 75%

Thought Disorganization 9.8% 76%

Blurred Vision 7.3% 83%

Irritability 7.3% 73%

Sweating 5.6% 80%

Memory Suppression 5.2% 75%

Amnesia 4.9% 95%

Muscle Tension 3.4% 70%

Increased Heart Rate 3.0% 70%

Seizure 2.6% 70%

Lightheadedness 2.4% 80%

Panic 2.4% 80%

Dysphoria 2.4% 85%

Sadness 2.4% 90%

Combinations TripSit

Pill Identifiers

4 known pill identifiers on record — view imprints, colors, shapes, and images

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Hydrocodone's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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