Home
    Disclaimer

    FXE

    Aliases: 3f-o-pce, fluorexetamine

    Dissociative

    Summary

    FXE is a dissociative. Reported effects include physical euphoria, pain relief, analgesia, and time distortion.

    Perspectives

    “FXE is a lot of fun, having tried it in its purified form, it is quickly earning a place among the pantheon of my favorite dissociatives. It is euphoric, creative, fairly visual, and quite psychedelic offering a great deal of stimulating cognitive enhancement.”

    Dose Information

    ROA Light Common Strong Heavy
    Oral BA ~50% 5-15mg 15-37.5mg 37.5-75mg 75mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects

    ROA Onset Peak Offset After Effects Total
    Oral 15-40 min 1-2 hrs 60-90 min 4-8 hrs 2-4 hrs

    Effect Profile

    7 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.0
    Strong 6/10

    Strong dissociative depth and motor impairment with mild mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection spatial disorientation perception of bodily lightness +2 more
    ⚠ Mania / Compulsion ×1
    4
    disinhibition stimulation
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki FXE
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Estimates are based on dissociative class patterns and user reports rather than controlled studies. Cross‑tolerance within arylcyclohexylamines is common; allowing 2–4+ weeks between sessions reduces tolerance significantly.

    Cross-Tolerances

    Ketamine
    70%
    MXE (Methoxetamine)
    70%
    O‑PCE
    70%
    2‑FDCK
    60%
    DXM
    50%

    Effects Erowid

    Aggregated from 7 Erowid experience reports

    Positive Effects 7

    Euphoria 85.7% 70%
    Empathy 85.7% 70%
    Color Enhancement 71.4% 70%
    Music Enhancement 71.4% 70%
    Stimulation 71.4% 70%
    Introspection 42.9% 70%
    Tactile Enhancement 42.9% 70%

    Adverse Effects 1

    Motor Impairment 42.9% 70%

    Combinations TripSit

    FXE's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 Bluelight 📖 PsychonautWiki