FXE - Substance Search

Summary

FXE is a dissociative. Reported effects include physical euphoria, pain relief, analgesia, and time distortion.

Perspectives

“FXE is a lot of fun, having tried it in its purified form, it is quickly earning a place among the pantheon of my favorite dissociatives. It is euphoric, creative, fairly visual, and quite psychedelic offering a great deal of stimulating cognitive enhancement.”

— Nervewing, nervewing.blogspot.com 170 mg intranasal

Dose Information

ROA	Light	Common	Strong	Heavy
Insufflated BA ~50%	5-15mg	15-37.5mg	37.5-75mg	75mg+

Light Common Strong Heavy

Onset, Duration & After-effects

ROA	Onset	Peak	Offset	After Effects	Total
Insufflated	15-40 min	1-2 hrs	60-90 min	4-8 hrs	2-4 hrs

Effect Profile

7 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 6.0

Strong 6/10

Strong dissociative depth and motor impairment with mild mania, low insight

Dissociative Depth ×3

10

depersonalization derealization physical disconnection visual disconnection spatial disorientation perception of bodily lightness +2 more

⚠ Mania / Compulsion ×1

4

disinhibition stimulation

Insight / Novel Thought ×2

3

conceptual thinking

⚠ Motor / Sensory Impairment ×1

10

motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more

Based on reports from:

Bluelight Big & Dandy Thread Erowid Experience Reports

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track FXE there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "FXE (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

FXE

Unit

mg

Description

FXE
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): threshold 2.5 · light 5-15 · common 15-37.5 · strong 37.5-75 · heavy 75+

Insufflated duration: onset 15-40m · peak 1-2h · offset 1-1.5h · total 2-4h · after-effects 4-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 26.25 mg (Insufflated).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 1d Half tolerance 14d Baseline ~28d

Estimates are based on dissociative class patterns and user reports rather than controlled studies. Cross‑tolerance within arylcyclohexylamines is common; allowing 2–4+ weeks between sessions reduces tolerance significantly.

Cross-Tolerances

Ketamine

70%

MXE (Methoxetamine)

70%

O‑PCE

70%

2‑FDCK

60%

DXM

50%

Effects Erowid

Aggregated from 7 Erowid experience reports

Positive Effects 7

Euphoria 85.7% 70%

Empathy 85.7% 70%

Color Enhancement 71.4% 70%

Music Enhancement 71.4% 70%

Stimulation 71.4% 70%

Introspection 42.9% 70%

Tactile Enhancement 42.9% 70%

Adverse Effects 1

Motor Impairment 42.9% 70%

Combinations

Cross-Check FXE with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 7 reports 4 positive 2 neutral 1 cautionary visit

Tripping into Love neutral exp #117106

Initially, we were just friends and had no plans for the trip that changed everything. Two years ago, I met a boy who was avoidant while I had a boyfriend. We formed a friendship that evolved into a larger group of like-minded people who bonded over their shared love for Research Chemicals and Techno.

The Great Void of Heaven positive exp #116413

[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] It is worth considering that the 170 mg dose I took here would be considered quite a heavy dose; my personal preference with dis...

Now We're Cooking positive exp #117852

In my friend group, one of our typical Friday night pastimes is consuming research chemicals and attempting to engage in some sort of technically demanding activity together in spite of their impairing effects.

No Time for Me to Properly Understand positive exp #116094

[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] An Evening with FXE 3-F-2'-Oxo-PCE / Fluorexetamine / FXE has finally made a proper debut in the research chemical scene.

The Mythic Calculus positive exp #116611

[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] Setting: a land far across the Atlantic, at a gathering of hard-core entymologists, night-time on a sandy river side.

FX-Meh (First Experiment White FXE Batch) neutral exp #117671

[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] ROA Insufflated Non stim batch Solid large white crystals. Purchased it 2022/2023 North America.

A Surprisingly Cognitive Dissociative cautionary exp #117756

[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] Context/Intent: One of my best friends from college was in town.

Bluelight 1 thread 1 neutral visit

Fxe Experienced 175 Mg Intranasal The Great Void Of Heaven neutral

Age: 26 Weight: 130 lbs Dosage: 170 mg intranasal Setting: My house It is worth considering that the 170 mg dose I took here would be considered quite a heavy dose; my personal preference with dissociatives is for higher doses and more exploratory experiences.

Bluelight Reference Guide Bluelight

Dissociatives The Big & Dandy Fluorexetamine (3-F-2’-oxo-PCE; FXE) Thread

I just noticed this listed on the site of one of my vendors. This is the first I have heard mention of it. It's MXE with the methoxy on the 3 position replaced by a fluorine.

Read full thread on Bluelight →

FXE's nerd page Pharmacology, chemical data, effect profiles, and more

→

Helpful Links

📘 Experience Reports 📖 Bluelight 📖 PsychonautWiki

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