Initially, we were just friends and had no plans for the trip that changed everything. Two years ago, I met a boy who was avoidant while I had a boyfriend. We formed a friendship that evolved into a larger group of like-minded people who bonded over their shared love for Research Chemicals and Techno.
FXE
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: 3f-o-pce, fluorexetamine
Summary
FXE is a dissociative. Reported effects include physical euphoria, pain relief, analgesia, and time distortion.
Perspectives
“FXE is a lot of fun, having tried it in its purified form, it is quickly earning a place among the pantheon of my favorite dissociatives. It is euphoric, creative, fairly visual, and quite psychedelic offering a great deal of stimulating cognitive enhancement.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~50% | 5-15mg | 15-37.5mg | 37.5-75mg | 75mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Insufflated | 15-40 min | 1-2 hrs | 60-90 min | 2-4 hrs |
Effect Profile
7 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.0
Strong
6/10
Strong dissociative depth and motor impairment with mild mania, low insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
visual disconnection
spatial disorientation
perception of bodily lightness
+2 more
Mania / Compulsion
×1
4
disinhibition
stimulation
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Estimates are based on dissociative class patterns and user reports rather than controlled studies. Cross‑tolerance within arylcyclohexylamines is common; allowing 2–4+ weeks between sessions reduces tolerance significantly.
Cross-Tolerances
Effects
Aggregated from 7 Erowid experience reports
Positive Effects 7
Euphoria
85.7%
70%
Empathy
85.7%
70%
Color Enhancement
71.4%
70%
Music Enhancement
71.4%
70%
Stimulation
71.4%
70%
Introspection
42.9%
70%
Tactile Enhancement
42.9%
70%
Adverse Effects 1
Motor Impairment
42.9%
70%
Combinations
Cross-Check FXE with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 1 positive 6 neutral visit
[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] It is worth considering that the 170 mg dose I took here would be considered quite a heavy dose; my personal preference with dis...
In my friend group, one of our typical Friday night pastimes is consuming research chemicals and attempting to engage in some sort of technically demanding activity together in spite of their impairing effects.
[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] An Evening with FXE 3-F-2'-Oxo-PCE / Fluorexetamine / FXE has finally made a proper debut in the research chemical scene.
[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] Setting: a land far across the Atlantic, at a gathering of hard-core entymologists, night-time on a sandy river side.
[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] ROA Insufflated Non stim batch Solid large white crystals. Purchased it 2022/2023 North America.
[Erowid Note: All samples of material sold as Fluorexetamine (FXE; 3-Fluoro-2-oxo PCE) and analyzed by Erowid's DrugsData service have contained other compounds, usually 2-Fluoro-2-oxo PCE .] Context/Intent: One of my best friends from college was in town.
Bluelight 1 thread 1 neutral visit
Age: 26 Weight: 130 lbs Dosage: 170 mg intranasal Setting: My house It is worth considering that the 170 mg dose I took here would be considered quite a heavy dose; my personal preference with dissociatives is for higher doses and more exploratory experiences.
Bluelight Reference Guide
Dissociatives The Big & Dandy Fluorexetamine (3-F-2’-oxo-PCE; FXE) Thread
I just noticed this listed on the site of one of my vendors. This is the first I have heard mention of it. It's MXE with the methoxy on the 3 position replaced by a fluorine.
Read full thread on Bluelight →
FXE's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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