First Steps With 2F-Ket 2-Fluoro-Deschloroketamine, also known as 2FDCK, 2F-Ketamine, 2F-Deschloroketamine, 2'-Oxo-PCM, and probably a few other things, is a wonderful and amazing chemical, an arylcyclohexylamine, NMDA receptor agonist, and dissociative anesthetic, the same type of drug as ketamine.
2-FDCK
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: 2-fk, 2f-ket, 2f-ketamine, Fluoroketamine, 2-fl-2'-oxo-pcm, 2-fluorodeschloroketamine, 2f-dck, 2fket, 2fdck
Summary
2-Fl-2'-Oxo-PCM (also known as 2-Fluorodeschloroketamine, 2-FDCK, and inaccurately as 2-Fluroketamine, Fluoroketamine, and 2-FK and known as CAS number: 111982-50-4) is a lesser-known novel dissociative substance of the arylcyclohexylamine class. It is chemically similar to ketamine and deschloroketamine (DCK). It is thought to act as an NMDA receptor antagonist, although research is currently limited.
Perspectives
“Itβs amazing just how much changing the ROA can change a drug. This frankly felt like a totally different substance than when it is dosed intranasally. There was absolutely zero rush with the oral ROA, it was a steady and certain immersion into the experience.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~50% | 10-45mg | 45-100mg | 100-175mg | 175mg+ |
| Oral | 10-25mg | 25-70mg | 70-140mg | 140mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-60 min | 45-90 min | 1-2 hrs | 1-2 hrs | 3-5 hrs |
| Insufflated | 4-19 min | 15-45 min | 1-2 hrs | 1-2 hrs | 2-4 hrs |
| Intramuscular | 4-10 min | 10-19 min | 1-2 hrs | 1-2 hrs | 2-4 hrs |
| Rectal | 10-30 min | 30-60 min | 1-2 hrs | 1-2 hrs | 2.5-4.5 hrs |
| Oral | 15-50 min | - | 0.83-1.67 hrs | - | 2.5-5 hrs |
Effect Profile
17 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
5.4
Moderate+
5/10
Strong dissociative depth, motor impairment, and mania with low insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
visual disconnection
spatial disorientation
memory suppression
Mania / Compulsion
×1
8
compulsive redosing
disinhibition
stimulation
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Cross-Tolerances
Dissociatives
Ketamine
80%
Dextromethorphan
80%
PCP
80%
Methoxetamine
80%
3-MeO-PCP
80%
3-HO-PCP
80%
3-MeO-PCE
80%
3-HO-PCE
80%
Effects
Aggregated from 17 Erowid experience reports
Positive Effects 8
Music Enhancement
58.8%
70%
Euphoria
52.9%
70%
Color Enhancement
52.9%
70%
Empathy
41.2%
70%
Focus Enhancement
35.3%
70%
Stimulation
35.3%
70%
Tactile Enhancement
29.4%
70%
Body High
29.4%
70%
Adverse Effects 6
Anxiety
58.8%
70%
Motor Impairment
35.3%
70%
Nausea
29.4%
70%
Confusion
23.5%
70%
Headache
17.6%
70%
Increased Heart Rate
17.6%
70%
Combinations
Cross-Check 2-FDCK with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 2 positive 5 neutral 1 cautionary visit
Dose timeline 16:55 (T +0:00) 2-FDCK (60mg, sublingual) 17:05 (T +0:10) 2-FDCK (80mg, sublingual) To preface, I have no experience with dissociative drugs, except for one salvia breakthrough. This was my very first experience with any ketamine substance; it happened less than 24 hours ago.
T0:00- Dose taken. T0:22- Onset, feeling a tad dizzy and numb in my extremities, a bit of tingling down my nerves. T0:28- IΒve been trying to respond to some reddit comment about structure/activity relations and hypothetical molecules that would fulfill certain receptor affinities.
T0:00 Β Suck down two fat mounds of powder- it has been quite a while since I have had to snort so much powder at once, and it is exceedingly unpleasant, as expected. It doesnΒt have the acrid petroleum odor and flavor of other arylcyclohexylamines, rather it is more of a musty, rancid smell.
[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects. Sometimes extremely high doses reported are errors rather than actual doses used.] This was the second time I had ever taken 2-FDCK.
13:00 10mg chemical drop & no other noticeable effects 13:15 10mg feels like IΒve had a glass of wine 13:25 10mg enjoying talking and feeling summer time kind of drunkness 13:40 20mg start to feel pretty light in my body and begin to enjoy the oncoming feelings.
Here's my trip report with 2F-DCK and I'm sorry for my english. It's been a while since I've I taken any psychoactive substances, the last time I took a psychedelic was in 2015. Now that I'm 33 yo, I wanted to re-discover some substances in a less festive context.
Dosing: T-7:00 150 mg bupropion sustained release tablet, oral (daily) T+0:00 103 mg 2-FCDK (120 mg 2-FCDK HCl crystals), rectal T+1:30 300 ml green tea, oral Previous experiences: alcohol, cannabis, several psychedelic and stimulant substances, some nootropics.
Bluelight 2 threads 2 neutral visit
2-FDCK (total β₯430 mg intranasal) - Experienced - Training blindsight, brainwave attenuation, yogic sleep 22 November, '19β Yesterday I finally received a shipment that I'd all but written off, which meant that I had 4 surprise grams of 2-FDCK on my hands.
My SO and I just got back from a weekend of fun, in which we both had some 4-HO-MET and 3 tabs of 1P. We decided Monday was as good as day as any to get wonky. I measured out 350mg and two promethazine for each of us. I was planning on just doing bumps all night.
Bluelight Reference Guide
Dissociatives The Big & Dandy 2-Fluorodeschloroketamine (2fk/2fdck) Thread
iupac = (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone / 2-(2-fluorophenyl)-2-(methylamino)cyclohexanone The full correct name is 2-fluorodeschloroketamine, also known as 2-Fl-2'-Oxo-PCM and 2-FDCK. Has been spotted in Sweden.
Read full thread on Bluelight β
2-FDCK's nerd page
Pharmacology, chemical data, effect profiles, and more
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