Preface: I am frankly not too experienced in the world of opioids, but I had the opportunity to obtain and try this fairly popular rc opioid. Tramadol itself is a unique opioid for its nonselective receptor activity, acting as a SNRI and 5HT2c antagonist.
O-DSMT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: O-Desmethyltramadol, odt, o-smt
Summary
O-Desmethyltramadol (also known as O-DSMT and desmetramadol) is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol.
Perspectives
“Perhaps it wasnโt good to dive into this class of drugs for what is ultimately a fairly non-standard experience from a non-standard substance. Ultimately, all pleasant and positive effects were overcome with the constant itching, deep and under my skin. It bordered on hellish at points.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 5-12.5mg | 12.5-25mg | 25-50mg | 50mg+ |
| Oral | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
| Sublingual | 10-25mg | 25-50mg | 50-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Intravenous | <1-1 min | - | 2-5 hrs | 2-4 hrs | 3-6 hrs |
| Oral | 18-42 min | 30-42 min | 2-5 hrs | 2-4 hrs | 6-8 hrs |
| Sublingual | 18-42 min | - | 2-5 hrs | 2-4 hrs | 3-6 hrs |
Effect Profile
10 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.1
Strong
6/10
Strong euphoria with moderate itching/nausea, mild pain relief and sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin ยท National Harm Reduction Coalition ยท WHO: opioid overdose ยท Merrall et al. 2010 ยท Binswanger et al. 2007 ยท Strang et al. 2003 ยท FDA 2019: gabapentinoids and breathing
Effects
Aggregated from 5 single-substance Erowid and 5 Bluelight experience reports; 4 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 5 single-substance Erowid and 5 Bluelight reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 14
9 of 10
90%
8 of 10
93%
4 of 5
88%
2 of 5
85%
2 of 5
85%
1 of 5
95%
1 of 5
90%
1 of 5
80%
1 of 5
80%
1 of 5
85%
1 of 5
80%
1 of 5
80%
1 of 5
80%
1 of 5
85%
Adverse Effects 8
3 of 5
90%
2 of 5
95%
2 of 5
88%
1 of 5
85%
1 of 5
80%
1 of 5
85%
1 of 5
80%
1 of 5
85%
Combinations
Cross-Check O-DSMT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 7 reports 2 positive 3 neutral 2 cautionary visit
Context: As someone experienced with most of the low-end and midrange opioids, Iยve been looking for alternatives to hydrocodone or oxycodone to help bridge pain-relief gaps. While prescribed 15mg of oxycodone daily, Iยve been taking between 30 to 60mg daily instead for the last two or three years.
The Addictive Nature of O-Desmethyltramadol Now that opiates are making headlines as the big thing that's going to get your kids like some chemical boogeyman (junior's own penchant for drugs doesn't seem to be quite as demonized, but I digress...), doctor's have become very stringent when it comes to prescribing pain m...
This opioid isnยt terribly common (yet) so I thought Iยd offer some general notes based on about four months of weekly dosing, followed by a three month break before I resumed.
Prior experiences: MDMA, cannabis, amphetamines, codeine, various poppy concoctions (opium, poppy tea) I recently acquired 1 gram of o-desmethyltramadol and would like to share my experiences of this chemical as there does not seem to be much literature posted regarding its dosage/effects.
For the sake of scientific research, I decided to try out a certain amount of products available from trusted online sources. Got myself the one narcotic that a specific source was selling : desmethyltramadol. I would like to specify what I think it truly is in terms of potential.
[Erowid Note: Interactions between opioids and other drugs can be very dangerous. By some estimates, over 95% of opioid-related deaths involve an opioid combined with at least one additional medication or drug, most commonly a sedative or depressant (alcohol, benzodiazepines, or another opioid).] In writing this I hope...
Bluelight 6 threads 3 positive 3 neutral visit
So Frank has been using this chemical for 3 weeks now, he went one week using it everyday but other than that used it with 3 day breaks. Frank had no opiate tolerance coming when he began using this as he had taken a 4 month break from all drugs, but did have a fair experience of Opiates and was very common with most d...
Subject: Male /19 years / 5,8 ft / ~210lbs My Experience with opioids: Codeina , Tramadol , AH-7921 (HCL) , O-DT Tolerance: Absence, at least two months ago last time I`m been using opioid Dosage: +/- 140mg of O-Desmethyltramadol Route of administration: Oral (P.O) 05:03 โ I take the bag with O-Desmethyltramadol and I...
Preface : Long story short, was dependent on opioids (IV morphine 300mgs, or Snorted oxycodone 160mgs) since 2007, but last use of any pharmaceutical opioid was January 2014 due to prison sentence.
Age: 18 years Weight: ~60 kilo Experience: mediocre with pretty much everything; with opioids: AH-7921, O-DMT, Codeine, Buprenorphine, Morphine Tolerance: between low and none. Rabbit cares about his tolerance so he can test compounds thoroughly and without losing magic and/or pleasure Desmethyltramadol.
Hi All! I don't usually write experience reports, but from my cursory google searches, there seem to be very, very few reports on this compound. I acquired 500mg recently from a very reputable source, and after allergy testing, I decided to test the waters. Some background: I am very opiate naive.
I ordered some o-dsmt online. I did an allergytest, put a little bit under my tongue and survived. I eyeballed 2x30mg, put them in cigarette paper and ate one. About an hour later nothing really happened, so I took the other 30ish mg. Another two hours later I was fairly disappointed.
O-DSMT's nerd page
Pharmacology, chemical data, effect profiles, and more
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