Summary
O-Desmethyltramadol (also known as O-DSMT and desmetramadol) is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 5-12.5mg | 12.5-25mg | 25-50mg | 50mg+ |
| Oral | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
| Sublingual | 10-25mg | 25-50mg | 50-80mg | 80mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Intravenous | 0 min | - | 2-5 hrs | 2-4 hrs | 1-3 hrs | 180-0 min |
| Oral | 18-42 min | 30-42 min | 2-5 hrs | 2-4 hrs | 1-3 hrs | 360-0 min |
| Sublingual | 18-42 min | - | 2-5 hrs | 2-4 hrs | 1-3 hrs | 180-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Pain Relief
Negative
- Motor impairment
- Nausea
- Sedation
- Itchiness
- Difficulty urinating
- Pupil constriction
Positive
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Euphoria
- Cognitive Euphoria
- Anxiety Suppression
- Dream Potentiation
Negative
- Constipation
- Dizziness
- Confusion
Positive
- Increased music appreciation
Negative
- Appetite suppression
- Double vision
- Decreased Libido
- Appetite Suppression
- Orgasm Suppression
- Acuity Suppression
- Dehydration
- Dulled perception
- Internal hallucination