Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    O-DSMT

    Aliases: O-Desmethyltramadol, odt, o-smt

    Depressant Opioid

    Summary PsychonautWiki

    O-Desmethyltramadol (also known as O-DSMT and desmetramadol) is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol.

    Perspectives

    “Perhaps it wasn’t good to dive into this class of drugs for what is ultimately a fairly non-standard experience. All pleasant and positive effects were overcome with the constant itching, deep and under my skin. It bordered on hellish at points.”

    Dose Information PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Intravenous 5-12.5mg 12.5-25mg 25-50mg 50mg+
    Oral 10-25mg 25-50mg 50-100mg 100mg+
    Sublingual 10-25mg 25-50mg 50-80mg 80mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 18-42 min 30-42 min 2-5 hrs 2-4 hrs 1-3 hrs 4.8-10.4 hrs
    Sublingual 18-42 min - 2-5 hrs 2-4 hrs 1-3 hrs 4.3-9.7 hrs

    Effect Profile

    14 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.7
    Intense 8/10

    Strong euphoria and pain relief with moderate itching/nausea, mild sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    8
    pain relief
    Sedation / Relaxation ×1
    4
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki O-DSMT
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Tolerance develops rapidly with daily use and decays over 1–2 weeks for most users; numbers are modelled from general opioid patterns and community reports rather than controlled O‑DSMT studies.

    Cross-Tolerances

    morphine
    80%
    codeine
    70%
    heroin
    80%
    tramadol
    60%
    oxycodone
    80%

    Effects Erowid Bluelight

    Aggregated from 9 Erowid and 5 Bluelight experience reports

    Positive Effects 17

    Body High 80.0% 88%
    Euphoria 78.6% 90%
    Sedation 71.5% 93%
    Empathy 44.4% 70%
    Tactile Enhancement 44.4% 70%
    Contentment 40.0% 85%
    Drowsiness 40.0% 85%
    Stimulation 35.7% 85%
    Anxiety Suppression 33.3% 70%
    Tingling 20.0% 95%
    Pain Relief 20.0% 90%
    Vivid Dreams 20.0% 80%
    Emotional Openness 20.0% 80%
    Hypersomnia 20.0% 80%
    Motor Enhancement 20.0% 80%
    Confidence Enhancement 20.0% 80%
    Joy 20.0% 85%

    Adverse Effects 8

    Itching 60.0% 90%
    Sweating 40.0% 95%
    Body Temperature Change 40.0% 88%
    Nausea 28.6% 80%
    Body Load 20.0% 85%
    Confusion 20.0% 85%
    Tremor 20.0% 80%
    Insomnia 20.0% 85%

    Combinations TripSit

    O-DSMT's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki 📖 TripSit