Preface: I am frankly not too experienced in the world of opioids, but I had the opportunity to obtain and try this fairly popular rc opioid. Tramadol itself is a unique opioid for its nonselective receptor activity, acting as a SNRI and 5HT2c antagonist.
O-DSMT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: O-Desmethyltramadol, odt, o-smt
Summary
O-Desmethyltramadol (also known as O-DSMT and desmetramadol) is an opioid substance of the phenylpropylamine class. It is an active metabolite of tramadol.
Perspectives
“Perhaps it wasnโt good to dive into this class of drugs for what is ultimately a fairly non-standard experience. All pleasant and positive effects were overcome with the constant itching, deep and under my skin. It bordered on hellish at points.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 5-12.5mg | 12.5-25mg | 25-50mg | 50mg+ |
| Oral | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
| Sublingual | 10-25mg | 25-50mg | 50-80mg | 80mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Intravenous | - | - | 2-5 hrs | 2-4 hrs | 3-6 hrs |
| Oral | 18-42 min | 30-42 min | 2-5 hrs | 2-4 hrs | 6-8 hrs |
| Sublingual | 18-42 min | - | 2-5 hrs | 2-4 hrs | 3-6 hrs |
Effect Profile
14 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
7.7
Intense
8/10
Strong euphoria and pain relief with moderate itching/nausea, mild sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
8
pain relief
Sedation / Relaxation
×1
4
sedation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
3d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance develops rapidly with daily use and decays over 1โ2 weeks for most users; numbers are modelled from general opioid patterns and community reports rather than controlled OโDSMT studies.
Effects
Aggregated from 9 Erowid and 5 Bluelight experience reports
Positive Effects 17
Body High
80.0%
88%
Euphoria
78.6%
90%
Sedation
71.5%
93%
Empathy
44.4%
70%
Tactile Enhancement
44.4%
70%
Contentment
40.0%
85%
Drowsiness
40.0%
85%
Stimulation
35.7%
85%
Anxiety Suppression
33.3%
70%
Tingling
20.0%
95%
Pain Relief
20.0%
90%
Vivid Dreams
20.0%
80%
Emotional Openness
20.0%
80%
Hypersomnia
20.0%
80%
Motor Enhancement
20.0%
80%
Confidence Enhancement
20.0%
80%
Joy
20.0%
85%
Adverse Effects 8
Itching
60.0%
90%
Sweating
40.0%
95%
Body Temperature Change
40.0%
88%
Nausea
28.6%
80%
Body Load
20.0%
85%
Confusion
20.0%
85%
Tremor
20.0%
80%
Insomnia
20.0%
85%
Combinations
Cross-Check O-DSMT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 6 neutral 1 cautionary visit
Context: As someone experienced with most of the low-end and midrange opioids, Iยve been looking for alternatives to hydrocodone or oxycodone to help bridge pain-relief gaps. While prescribed 15mg of oxycodone daily, Iยve been taking between 30 to 60mg daily instead for the last two or three years.
The Addictive Nature of O-Desmethyltramadol Now that opiates are making headlines as the big thing that's going to get your kids like some chemical boogeyman (junior's own penchant for drugs doesn't seem to be quite as demonized, but I digress...), doctor's have become very stringent when it comes to prescribing pain m...
This opioid isnยt terribly common (yet) so I thought Iยd offer some general notes based on about four months of weekly dosing, followed by a three month break before I resumed.
Prior experiences: MDMA, cannabis, amphetamines, codeine, various poppy concoctions (opium, poppy tea) I recently acquired 1 gram of o-desmethyltramadol and would like to share my experiences of this chemical as there does not seem to be much literature posted regarding its dosage/effects.
For the sake of scientific research, I decided to try out a certain amount of products available from trusted online sources. Got myself the one narcotic that a specific source was selling : desmethyltramadol. I would like to specify what I think it truly is in terms of potential.
[Erowid Note: Interactions between opioids and other drugs can be very dangerous. By some estimates, over 95% of opioid-related deaths involve an opioid combined with at least one additional medication or drug, most commonly a sedative or depressant (alcohol, benzodiazepines, or another opioid).] In writing this I hope...
Bluelight 6 threads 6 neutral visit
So Frank has been using this chemical for 3 weeks now, he went one week using it everyday but other than that used it with 3 day breaks. Frank had no opiate tolerance coming when he began using this as he had taken a 4 month break from all drugs, but did have a fair experience of Opiates and was very common with most d...
Subject: Male /19 years / 5,8 ft / ~210lbs My Experience with opioids: Codeina , Tramadol , AH-7921 (HCL) , O-DT Tolerance: Absence, at least two months ago last time I`m been using opioid Dosage: +/- 140mg of O-Desmethyltramadol Route of administration: Oral (P.O) 05:03 โ I take the bag with O-Desmethyltramadol and I...
Preface : Long story short, was dependent on opioids (IV morphine 300mgs, or Snorted oxycodone 160mgs) since 2007, but last use of any pharmaceutical opioid was January 2014 due to prison sentence.
Age: 18 years Weight: ~60 kilo Experience: mediocre with pretty much everything; with opioids: AH-7921, O-DMT, Codeine, Buprenorphine, Morphine Tolerance: between low and none. Rabbit cares about his tolerance so he can test compounds thoroughly and without losing magic and/or pleasure Desmethyltramadol.
Hi All! I don't usually write experience reports, but from my cursory google searches, there seem to be very, very few reports on this compound. I acquired 500mg recently from a very reputable source, and after allergy testing, I decided to test the waters. Some background: I am very opiate naive.
I ordered some o-dsmt online. I did an allergytest, put a little bit under my tongue and survived. I eyeballed 2x30mg, put them in cigarette paper and ate one. About an hour later nothing really happened, so I took the other 30ish mg. Another two hours later I was fairly disappointed.
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