Tramadol is a quasi-narcotic analgesic used in the treatment of moderate to severe pain. It is a synthetic analog of codeine, but has a low binding affinity to the mu-opioid receptors. It has been prescribed off-label for the treatment of diabetic neuropathy and restless leg syndrome.
⚠ Equianalgesic dose ratios are approximations and do not account for
genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations.
Methadone conversion is especially variable at higher doses.
Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
453 reports
Scores (1–10) curated from multiple sources:
Effect keyword matching from PsychonautWiki catalog
Validated against 403 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)
Build-updevelops over weeks of regular use; serotonergic effects may not show the same tolerance curve
Reset7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
21dHalf tolerance
7dBaseline
~28d
Clinical and user data indicate tolerance to both opioid and monoaminergic effects develops with repeated use; decay is gradual over weeks after cessation. Data quality is mixed and individualized.