Summary
Roughly 2-3× the potency of racemic ketamine with a markedly longer duration. Produces strong dissociation that can turn dysphoric or delusional at high doses. Urinary and bladder toxicity similar to or worse than ketamine has been reported with heavy use. Psychosis-like reactions, mania, and persisting cognitive deficits observed after chronic binges. Pure free-base easily aerosolizes and accidental inhalation can lead to rapid blackout.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-25mg | 25-40mg | 40+mg+ |
| Insufflated | 5-15mg | 15-25mg | 25-50mg | 50mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 5-30 min | 30-60 min | 1.5-2.5 hrs | 1-2 hrs | 3-24 hrs | 180-0 min |
| Insufflated | 2-10 min | 15-30 min | 60-90 min | 30-60 min | 1-12 hrs | 120-0 min |
| Smoked | 1-2 min | 5-15 min | 10-30 min | 15-30 min | 1-6 hrs | 180-0 min |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Analgesia
- Body lightness
- Creativity enhancement
- Physical euphoria
- Muscle relaxation
- Spontaneous tactile sensations
Negative
- Nausea
- Sedation
- Tactile disconnection
- Physical disconnection
Positive
- Anxiety suppression
- Cognitive euphoria
- Conceptual thinking
- Dream potentiation
- Immersion enhancement
- Analysis enhancement
Negative
- Cognitive disconnection
- Compulsive redosing
- Depersonalization
- Derealization
- Dizziness
- Memory suppression
- Motor control loss
- Amnesia
- Anxiety
- Information processing suppression
- Language suppression
- Thought deceleration
- Consciousness disconnection
- Ego dissolution
- Time distortion
- Perspective alterations
- Perspective distortions
- Physical autonomy
Positive
- Increased music appreciation
Negative
- Double vision
- Spatial disorientation
- Tactile suppression
- Acuity suppression
- Auditory suppression
- Disinhibition
- Frame rate suppression
- Pattern recognition suppression
- Closed-eye visuals
- Visual disconnection
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- Environmental cubism
- Environmental orbism
- Internal hallucinations
- Perception of decreased weight
- Scenery slicing
- Visual sliding