2C-I
Aliases: 2ci
Summary
2,5-Dimethoxy-4-iodophenethylamine (also known as 2C-I and "Smiles") is a psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. 2C-I was first synthesized and investigated for human activity by Alexander Shulgin in 1976 and later described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").
Perspectives
“The 2C family can feel like entirely different drugs depending on how you administer them. The oral ROA is an entirely different experience than insufflated—you come up fast and hard, faceplanted into the experience from the top of a 12 story building.”
“I was present at a group meeting, but was only an observer. With zero milligrams of 2C-I, I was able to get to a delightful plus 2.5 in about five minutes after I arrived at your place, and absorbed the ambience of the folks who had actually imbibed the material. My level lasted about four hours and came down at about the same time as did the others. There were no after-effects experienced except for a pleasant languor.”
“Overall, on this dose this was a fairly mild and pleasant experience. It didn't have the depth of 2C-E, or a great deal of excitement, but for a gentle afternoon sojourn it was positive and enjoyable.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | - | 5-10mg | 10mg | 10mg+ |
| Oral | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 0.75-2 hrs | - | 4-8 hrs | 1-2 hrs | - |
| Oral | 12-48 min | 48-90 min | 3-5 hrs | 2-3 hrs | 5-10 hrs |
Effect Profile
650 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 508 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, auditory effects, and body load
Tolerance
Effects
Aggregated from 508 Erowid and 142 Bluelight experience reports
Positive Effects 77
Adverse Effects 42
Combinations
Trip Reports
PiHKAL / TiHKAL
“I was present at a group meeting, but was only an observer. With zero milligrams of 2C-I, I was able to get to a delightful plus 2.5 in about five minutes after I arrived at your place, and absorbed the ambience of the folks who had actually imbibed the material. My level lasted about four hours and came down at about the same time as did the others. There were no after-effects experienced except for a pleasant languor.”