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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1D-LSD Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)
    • dose ladder unverifiable and undisclosed β€” capped

    Aliases: Syn-l-229

    Summary dose.wiki

    1D-LSD is a prodrug of LSD with a 1,2-dimethylcyclobutane-1-carbonyl group at the N1 position. User reports suggest it is approximately 15-25% less potent by weight than LSD-25, though this varies between individuals and batches. Some blotters sold as 1D-LSD have been found to contain 1T-LSD (1-thienoyl-LSD) instead; reagent tests confirm lysergamide presence but cannot distinguish between analogues.

    Perspectives

    “It bore all the hallmarks of a lysergamide- patterned intentional visuals, teal-pink color schemes, a long duration with a drawn out euphoric stimulating afterglow, analytical, sentimental, profound and joyous headspace. This is certainly a compound that offers a worthwhile experience.”

    Dose Information dose.wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    ROA Light Common Strong Heavy
    Oral 25-75Β΅g 75-150Β΅g 150Β΅g+ -
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki

    ROA Onset Peak Total
    Oral 30-60 min 4-6 hrs 10-14 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.4
    Moderate+ 5/10

    Strong visuals with moderate body load, mild headspace

    Visual Intensity ×3
    8
    visual geometry color enhancement tracers pattern recognition enhancement
    Headspace Depth ×3
    5
    conceptual thinking thought connectivity time distortion
    Auditory Effects ×1
    0
    Body Load / Somatic Effects ×1
    6
    nausea vasoconstriction increased heart rate
    Based on reports from:

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 1D-LSD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    1D-LSD
    Unit
    Β΅g
    Description
    1D-LSD
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (Β΅g): threshold 25 Β· light 25-75 Β· common 75-150 Β· strong 150+
    
    Oral duration: onset 0.5-1h Β· peak 4-6h Β· total 10-14h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 112.5 Β΅g (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    90%
    Tryptamines
    Psilocin
    80%
    DMT
    80%
    5-MeO-DMT
    80%
    Phenethylamines
    Mescaline
    60%
    2C-B
    60%
    2C-E
    60%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 2

    Music Enhancement 100.0% 70%
    Stimulation 75.0% 70%

    Adverse Effects 1

    Anxiety 75.0% 70%

    Combinations

    Cross-Check 1D-LSD with another substance

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