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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-AcO-DPT

    Aliases: Depracetin, 4acodpt

    Psychedelic Research-chemical

    Summary TheDrug.Wiki TripSit

    4-AcO-DPT is a research chemical tryptamine first reported around 2012 that acts as a prodrug to 4-HO-DPT through rapid de-acetylation. User reports indicate relatively poor oral bioavailability; intranasal or rectal routes produce shorter but more efficient experiences at roughly half oral doses, though insufflation can cause sharp stinging. The compound produces colorful, fast-moving visuals with pronounced physical stimulation including tremor, jaw tension, and visceral body load, yet comparatively less mystical depth than classic psychedelics.

    Perspectives

    “This substance is miraculously mentally stimulating. It feels as though it has boundless potential for introspection, therapy, learning, and analytical thinking. Rational, logical and completely anchored.”

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 10-15mg 15-25mg 25-35mg 35mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-60 min 30-60 min 1-2 hrs 1-2 hrs 2-8 hrs
    Insufflated 5-10 min 10-25 min 30-60 min 1-2 hrs 2-8 hrs
    Rectal 10-25 min 20-40 min 45-90 min 1-2 hrs 2-8 hrs

    Effect Profile

    5 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.4
    Moderate 4/10

    Moderate visuals with mild body load and headspace

    Visual Intensity ×3
    6
    color enhancement drifting tracers
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    5
    nausea teeth grinding increased heart rate
    Based on reports from:
    Effect Index Greater Mind Lesser Body Erowid Experience Reports PsychonautWiki 4-AcO-DPT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    30%
    Tryptamines
    Psilocybin
    30%
    Psilocin
    30%
    DMT
    30%
    5-MeO-DMT
    30%
    Phenethylamines
    Mescaline
    30%
    2C-B
    30%
    2C-E
    30%

    Effects Erowid

    Aggregated from 5 Erowid experience reports

    Positive Effects 7

    Color Enhancement 100.0% 70%
    Stimulation 100.0% 70%
    Euphoria 60.0% 70%
    Introspection 60.0% 70%
    Empathy 60.0% 70%
    Focus Enhancement 60.0% 70%
    Tactile Enhancement 60.0% 70%

    Adverse Effects 1

    Anxiety 80.0% 70%

    Combinations TripSit

    Trip Reports Effect Index

    Greater Mind Lesser Body nervewing
    4-AcO-DPT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki