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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-AcO-DPT Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Depracetin, 4acodpt

    Psychedelic Research-chemical

    Summary dose.wiki TripSit

    4-AcO-DPT is a research chemical tryptamine first reported around 2012 that acts as a prodrug to 4-HO-DPT through rapid de-acetylation. User reports indicate relatively poor oral bioavailability; intranasal or rectal routes produce shorter but more efficient experiences at roughly half oral doses, though insufflation can cause sharp stinging. The compound produces colorful, fast-moving visuals with pronounced physical stimulation including tremor, jaw tension, and visceral body load, yet comparatively less mystical depth than classic psychedelics.

    Perspectives

    “This substance is miraculously mentally stimulating. It feels as though it has boundless potential for introspection, therapy, learning, and analytical thinking.”

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 10-15mg 15-25mg 25-35mg 35mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 30-60 min 1-2 hrs 1-2 hrs 2-8 hrs 3-6 hrs
    Insufflated 5-10 min 10-25 min 30-60 min 1-2 hrs 2-8 hrs 1.75-3.59 hrs
    Rectal 10-25 min 20-40 min 45-90 min 1-2 hrs 2-8 hrs 2.25-4.59 hrs

    Effect Profile

    5 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.4
    Moderate 4/10

    Moderate visuals with mild body load and headspace

    Visual Intensity ×3
    6
    color enhancement drifting tracers
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    5
    nausea teeth grinding increased heart rate
    Based on reports from:
    Effect Index Greater Mind Lesser Body Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-AcO-DPT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-AcO-DPT (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-AcO-DPT
    Unit
    mg
    Description 
    4-AcO-DPT
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10
Insufflated dose (mg): light 10-15 · common 15-25 · strong 25-35 · heavy 35+
Rectal dose (mg): threshold 7

Oral duration: onset 0.5-1h · come-up 0.5-1h · peak 1-2h · offset 1-2h · total 3-6h · after-effects 2-8h
Insufflated duration: onset 5-10m · come-up 10-25m · peak 0.5-1h · offset 1-2h · total 1.75-3.59h · after-effects 2-8h
Rectal duration: onset 10-25m · come-up 20-40m · peak 0.75-1.5h · offset 1-2h · total 2.25-4.59h · after-effects 2-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    30%
    Tryptamines
    Psilocybin
    30%
    Psilocin
    30%
    DMT
    30%
    5-MeO-DMT
    30%
    Phenethylamines
    Mescaline
    30%
    2C-B
    30%
    2C-E
    30%

    Effects Erowid

    Aggregated from 5 Erowid experience reports

    Positive Effects 7

    Color Enhancement 100.0% 70%
    Stimulation 100.0% 70%
    Euphoria 60.0% 70%
    Introspection 60.0% 70%
    Empathy 60.0% 70%
    Focus Enhancement 60.0% 70%
    Tactile Enhancement 60.0% 70%

    Adverse Effects 1

    Anxiety 80.0% 70%

    Combinations

    Cross-Check 4-AcO-DPT with another substance

    Trip Reports Effect Index

    Greater Mind Lesser Body nervewing

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 2 reports 1 positive 1 neutral visit
    Greater Mind Lesser Body neutral exp #112158

    T0:00 - Cut the tan powder into a line and snort it. I was expecting the nightmares of the other members of this family I had the displeasure of consuming (DPT and 4-HO-DPT), where large piles of the chalky and retchingly bitter stinging powder had to be sucked down. Those ones dosed in the 70-100 mg range.

    nervewing
    A Mirror to the Mind positive exp #94380

    Setting: a wilderness trail in the Southwestern U.S., on a gorgeous January afternoon. 20 milligrams 4-AcO-DPT fumarate is insufflated. Within minutes, I can feel an indescribable, perhaps slightly dissociative sensation creeping through my body, and I'm beginning to clearly disconnect from sobriety in a somewhat famil...

    TheAppleCore · 20 mg insufflated
    4-AcO-DPT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki