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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-HO-DPT

    Aliases: Procin, 4-hydroxy-n, N-dipropyltryptamine, 4hodpt

    Psychedelic Research-chemical

    Summary PsychonautWiki

    4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes referred to as Procin) is a psychedelic substance of the tryptamine class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT.

    Perspectives

    “4-HO-DPT like its cousin DPT is an incredibly deep, strange, alien, and biomorphic psychedelic. The major obstacle is the absolutely horrendous ROA and the crippling bodyload, substantially worse than DPT.”

    “Possible threshold, nothing more.”

    Dose Information TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 40-60mg 60-90mg 90-130mg 130mg+
    Insufflated 10-15mg 15-25mg 25-35mg 35mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset
    Oral 48-60 min 1-2 hrs 2-3 hrs 1-2 hrs
    Insufflated 12-48 min 30-48 min 1-3 hrs 1-2 hrs

    Effect Profile

    5 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 7.0
    Strong+ 7/10

    Strong visuals and auditory effects with mild headspace and body load

    Visual Intensity ×3
    10
    color enhancement tracers drifting pattern recognition enhancement scenery slicing color shifting +3 more
    Headspace Depth ×3
    4
    conceptual thinking personal bias suppression time distortion
    Auditory Effects ×1
    8
    auditory distortion auditory hallucination
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    Based on reports from:
    Effect Index Sick off of Alien Resplendence TiHKAL TiHKAL #20: 4-HO-DPT Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 4-HO-DPT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    80%
    Tryptamines
    Psilocybin
    85%
    Psilocin
    85%
    DMT
    85%
    5-MeO-DMT
    85%
    Phenethylamines
    Mescaline
    65%
    2C-B
    65%
    2C-E
    65%

    Effects Erowid

    Aggregated from 5 Erowid experience reports

    Positive Effects 4

    Color Enhancement 80.0% 70%
    Music Enhancement 60.0% 70%
    Stimulation 60.0% 70%
    Tactile Enhancement 60.0% 70%

    Adverse Effects 0

    Combinations TripSit

    Trip Reports Effect Index

    Sick off of Alien Resplendence nervewing

    PiHKAL / TiHKAL Shulgin

    TiHKAL #20: 4-HO-DPT

    “Possible threshold, nothing more.”

    — Alexander Shulgin, TiHKAL (with 20 mg, orally)
    4-HO-DPT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki 📖 Bluelight