This was my first experience with this drug. I took this amount because I had heard that 4-HO-DPT was less potent by mass than other 4-substituted tryptamines, and read a trip report on this dose that led me to believe it would be around the intensity of perhaps 35-45 mg of 4-AcO-DMT. I was wrong.
4-HO-DPT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Procin, 4-hydroxy-n, N-dipropyltryptamine, 4hodpt
Summary
4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes referred to as Procin) is a psychedelic substance of the tryptamine class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT.
Perspectives
“4-HO-DPT like its cousin DPT is an incredibly deep, strange, alien, and biomorphic psychedelic that seems like it has a lot to offer, high doses seem to show the potential for some really interesting entity contact, or perhaps this is best done through combining it with other substances. The major obstacle is the absolutely horrendous ROA and the crippling bodyload.”
“Possible threshold, nothing more.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-60mg | 60-90mg | 90-130mg | 130mg+ |
| Insufflated | 10-15mg | 15-25mg | 25-35mg | 35mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 48-60 min | 1-2 hrs | 2-3 hrs | 1-2 hrs | 4.8-8 hrs |
| Insufflated | 12-48 min | 30-48 min | 1-3 hrs | 1-2 hrs | 2.7-6.6 hrs |
Effect Profile
5 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
7.0
Strong+
7/10
Strong visuals and auditory effects with mild headspace and body load
Visual Intensity
×3
10
color enhancement
tracers
drifting
pattern recognition enhancement
scenery slicing
color shifting
+3 more
Headspace Depth
×3
4
conceptual thinking
personal bias suppression
time distortion
Auditory Effects
×1
8
auditory distortion
auditory hallucination
Body Load / Somatic Effects
×1
4
nausea
increased heart rate
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes 4-HO-DPT, but its built-in data can be thinner than ours. Importing this file adds a separate "4-HO-DPT (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
⬇ Download import file
Import this file as custom substances
and you get "4-HO-DPT (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 5 Erowid experience reports
Positive Effects 4
Color Enhancement
80.0%
70%
Music Enhancement
60.0%
70%
Stimulation
60.0%
70%
Tactile Enhancement
60.0%
70%
Adverse Effects 0
Combinations
Cross-Check 4-HO-DPT with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 1 positive 1 neutral 1 cautionary visit
T0:00-Powder insufflated. This was one of the most unpleasant drug administration experiences I have ever had. The powder smells acrid, like something rotten. It is also incredibly fine and chalky. The act of insufflating it disturbed it enough to fluff it into big dust clouds in my throat and sinuses.
7-18-19 100mg Tried to dissolve in water. I swirled it around for about 10 mins, but it didnt work, so I just drank it. 900pm, 100mg 4hodpt down the hatch. According to Psychonaut Wiki, this will be a strong dose. TripSit says this is a [strong to] heavy dose. We'll see.
Bluelight Reference Guide
Tryptamines The Big & Dandy 4-HO-DPT Thread
The Big & Dandy 4-HO-DPT Thread [original post:] Does anybody know anything about this compound? I've tried searching. I would assume it's active...
Read full thread on Bluelight →PiHKAL / TiHKAL
TiHKAL #20: 4-HO-DPT
“Possible threshold, nothing more.”
4-HO-DPT's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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