This trip report marks my second experience with LSZ (my previous experience being 225ug a few weeks prior). Whilst I have various experience with AL-LAD (ranging up to 600ug), I can safely say that this will rank as one of the most intense and life-changing psychedelic experiences of my life. The story is this.
LSZ
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 7 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 7 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: Lambda, La-ss-az, Diazedine
Summary
Lysergic acid 2,4-dimethylazetidide (also known as Ξ», Lambda, and LSZ) is a synthetic psychedelic of the lysergamide chemical class which produces LSD-like psychedelic effects when administered. In the 2000s, a team led by David E. Nichols at Purdue University set to develop a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor.
Perspectives
“LSZ ticks all the boxes for a lysergamideβa degree of stimulation, a long duration, cognitive and emotional enhancement, and standard fare sensory effects. It should scratch the itch for anyone seeking such an experience.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-150Β΅g | 150-300Β΅g | 300-400Β΅g | 400Β΅g+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-60 min | 30-60 min | 3-5 hrs | 2-3 hrs | 6-10 hrs |
Effect Profile
24 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 24 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.5
Intense
8/10
Strong visuals, headspace, body load, and auditory effects
Visual Intensity
×3
10
color enhancement
autonomous entities
drifting
tracers
pattern recognition enhancement
colour shifting
+4 more
Headspace Depth
×3
10
conceptual thinking
emotion enhancement
perspective distortions
personal bias suppression
thought loops
time distortion
+1 more
Auditory Effects
×1
8
Body Load / Somatic Effects
×1
10
nausea
muscle tension
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 24 Erowid experience reports
Positive Effects 9
Music Enhancement
79.2%
70%
Euphoria
54.2%
70%
Stimulation
50.0%
70%
Color Enhancement
45.8%
70%
Introspection
41.7%
70%
Tactile Enhancement
25.0%
70%
Focus Enhancement
25.0%
70%
Empathy
20.8%
70%
Body High
20.8%
70%
Adverse Effects 6
Anxiety
50.0%
70%
Muscle Tension
50.0%
70%
Nausea
33.3%
70%
Confusion
25.0%
70%
Pupil Dilation
16.7%
70%
Jaw Clenching
12.5%
70%
Combinations
Cross-Check LSZ with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 1 positive 5 neutral 2 cautionary visit
Preface: LSZ at first glance seems like a really arbitrary way to modify the LSD molecule- a structure completely out of left field, where in place of the diethyl ΒhornsΒ of the LSD molecule, there is an azetidide group, a tense ring structure that is rarely seen in any bioactive molecules.
I would like to take this opportunity to dedicate this report to the memory of Sepher, Research In Peace to Sepher, & blessings to all those who came before us & all those to come! 11:15am half blotter, 75ug, gummed 11:40 possible alerts, light head, vague feeling of pull at back of neck, very common first alert for me...
First of all I want to apologise all readers for my English as it is not my native language. Quick introduction: Saturday evening, after a busy day, alone in my place.
Recently I ordered a few things, one of the things being a single tab of 150mcg LSZ. I was planning on taking something else I've never tried, but at the last second, I just popped the tab under my tongue. There was basically no flavor at all, maybe a slightly bitter/metallic taste.
Backwoods and LSZ It was the final night at Backwoods music festival, and I had already taken mushrooms on the first night and drank on the second. So I was looking to finish the weekend off with some LSD.
A few days ago I finally got to experience that psychedelic experience I had always dreamed of, LSD. I have had a great deal of experience with psychedelics in the past: psilocybin, 2-CI, 25b, salvia and something else which was most likely another phenylethylamine.
5 Months ago I decided to drop acid for the 2nd time. The first time I tried LSD it wasn't a completely a pleasant experience but it intrigued me enough to try it again now that I had a better idea of what to expect. This time I tried LSZ which is an analog of LSD.
Bluelight 8 threads 1 positive 7 neutral visit
This trip report marks my second experience with LSZ (my previous experience being 225ug a few weeks prior). Whilst I have various experience with AL-LAD (ranging up to 600ug), I can safely say that this will rank as one of the most intense and life-changing psychedelic experiences of my life. The story is this.
Age: 25 Weight: 130 lbs Dosage: 300 Β΅g sublingual Setting: Around the city *You can skip the chem talk if you want. The paragraph after that outlines the setting and intentions for the day, and per usual, a tl;dr explanation at the end.* Preface: LSZ at first glance seems like a really arbitrary way to modify the LSD m...
Set/Setting: At home, a quiet night in after working all week. Not in the best head space but not really in bad head space. At the crossroads in the life. Things are finally headed in a positive, albeit stressful direction. Looking for some inspiration to quit wallowing in the past and get my life together already.
6:30 PM- 450 ug ingested. 7:15- Alert in the form of increased salivation, chemical taste secondary to post-oral activation. The paper was taken in and swallowed immediately, just to rule out presence of Nbomes by virtue of oral ROA.
11:15am half blotter, 75ug, gummed 11:40 possible alerts, light head, vague feeling of pull at back of neck, very common first alert for me. Jumped up after a half hour of deep breathing & meditative thought, rinsed out some clothes & hung 'em up in the sunshine.
So I recently purchased some LSZ from a rather well-known and seemingly high regarded online vendor. My previous experience with psychedelics includes 1.5g of shrooms and 150ug of AL-LAD (I don't actually know if it was Aladdin or not because I got it from the same source as the LSZ, and after last night's experience I...
Finally got round to trying this relative of LSD. I was quite curious how this would compare to its cousins... I suppose everyone who has this has it from the same source more or less, the blotter being with molecule on one side and LSZ printed on the back.
This narrative is fictional and depicts an imaginary experience. Dose: LSZ, 150ug Duration: 10 hours, ingestion to baseline ***** tldr version: Minimally visual. Tremendous enhancement of music and movement. Enhancement of taste. Peak experience was a weak +2. An excellent substance for a night out dancing.
Bluelight Reference Guide
Lysergamides The Big & Dandy LSZ Thread
Welcome to the LSZ Thread LSD (left) ; LSZ (right) Formula = Lysergic Acid 2,4-dimethylazetidide (LA-SS-Az, LSZ, LSz) - Usually the (S,S)-(+) isomer http://en.wikipedia.org/wiki/Lysergic_acid_2,4-dimethylazetidide Bluelight Trip Reports: 1 1/2 blotters - First Time - Midnight Delight Untitled 450 ug LSZ report by The S...
Read full thread on Bluelight β
LSZ's nerd page
Pharmacology, chemical data, effect profiles, and more
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