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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    LSZ

    Aliases: Lambda, La-ss-az, Diazedine

    Psychedelic Research-chemical

    Summary Erowid TripSit PsychonautWiki

    Lysergic acid 2,4-dimethylazetidide (also known as Ξ», Lambda, and LSZ) is a synthetic psychedelic of the lysergamide chemical class which produces LSD-like psychedelic effects when administered. In the 2000s, a team led by David E. Nichols at Purdue University set to develop a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor.

    Perspectives

    “LSZ ticks all the boxes for a lysergamideβ€”a degree of stimulation, a long duration, cognitive and emotional enhancement, and standard fare sensory effects. It should scratch the itch for anyone seeking such an experience.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-150Β΅g 150-300Β΅g 300-400Β΅g 400Β΅g+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 30-60 min 3-5 hrs 2-3 hrs 6-24 hrs 6-10 hrs

    Effect Profile

    24 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 24 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.5
    Intense 8/10

    Strong visuals, headspace, body load, and auditory effects

    Visual Intensity ×3
    10
    color enhancement autonomous entities drifting tracers pattern recognition enhancement colour shifting +4 more
    Headspace Depth ×3
    10
    conceptual thinking emotion enhancement perspective distortions personal bias suppression thought loops time distortion +1 more
    Auditory Effects ×1
    8
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea muscle tension
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki LSZ The Drug Users Bible LSZ
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    90%
    Tryptamines
    Psilocybin
    80%
    Psilocin
    80%
    DMT
    80%
    5-MeO-DMT
    80%
    Phenethylamines
    Mescaline
    60%
    2C-B
    60%
    2C-E
    60%

    Effects Erowid

    Aggregated from 24 Erowid experience reports

    Positive Effects 9

    Music Enhancement 79.2% 70%
    Euphoria 54.2% 70%
    Stimulation 50.0% 70%
    Color Enhancement 45.8% 70%
    Introspection 41.7% 70%
    Tactile Enhancement 25.0% 70%
    Focus Enhancement 25.0% 70%
    Empathy 20.8% 70%
    Body High 20.8% 70%

    Adverse Effects 6

    Anxiety 50.0% 70%
    Muscle Tension 50.0% 70%
    Nausea 33.3% 70%
    Confusion 25.0% 70%
    Pupil Dilation 16.7% 70%
    Jaw Clenching 12.5% 70%

    Combinations TripSit

    LSZ's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    πŸ“˜ Experience Reports πŸ“– TheDrug.Wiki πŸ“– PsychonautWiki πŸ“– Bluelight πŸ“– The Drug Users Bible