Home
    Disclaimer
    ⚠ This substance involves MAOI activity. Dangerous interactions can occur with many common foods and medications. Research contraindications thoroughly.

    Ayahuasca

    Aliases: Aya, Cipó, Yage, Yaje, Brew, pharmahuasca

    Psychedelic Stimulant Empathogen

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Ayahuasca is a brew combining DMT-containing plants with MAOI-containing plants, requiring both components to produce psychoactive effects. Traditional brews vary widely in potency depending on plant sources, preparation methods, and regional practices. The purgative effects (nausea, vomiting, diarrhea) are considered an integral part of the traditional experience and can be intense.

    Dose Information TheDrug.Wiki PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Oral (Traditional B. Caapi + P. Viridis Brew) Smallcup(50-75mloftraditionalbrew) - Largecup(150-200mloftraditionalbrew) Multipleservingsorveryconcentratedbrew+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral (Syrian Rue + Mimosa Hostilis) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 5-10 hrs
    Oral (Syrian Rue + Acacia Confusa) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs
    Oral (Pharmahuasca - Extracted Alkaloids) 15-30 min 19-40 min 1-2 hrs 1-2 hrs 1-6 hrs 4-8 hrs
    Oral (Traditional B. Caapi + P. Viridis Brew) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs
    Oral 18-60 min - 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs

    Effect Profile

    166 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 141 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    internal hallucinations autonomous entity contact autonomous entities colour enhancement synesthesia drifting +7 more
    Headspace Depth ×3
    10
    conceptual thinking personal meaning enhancement thought connectivity emotional amplification and catharsis feelings of interdependent opposites subconscious communication +8 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations synesthesia
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea physical discomfort muscle tension
    Empathogen 9.1
    Intense+ 9/10

    Strong sensory enhancement, empathy, euphoria, and stimulation

    Empathy / Social Openness ×3
    9
    empathy
    Euphoria / Mood Elevation ×2
    9
    euphoria emotion enhancement
    Stimulation ×1
    9
    stimulation restlessness
    Sensory Enhancement ×1
    10
    enhanced tactile sensation spontaneous tactile sensations colour enhancement acuity enhancement
    Stimulant 6.6
    Strong+ 7/10

    Strong anxiety/jitters and focus with moderate stimulation and euphoria

    Stimulation / Energy ×3
    7
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria
    Focus / Productivity ×2
    9
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    restlessness muscle tension
    Based on reports from:
    Effect Index My First Experience with Unity Effect Index My First Proper Psychedelic Experience Effect Index My Second Experience with Unity Effect Index Best Cake I've Had for a While Effect Index Trying to Engage in Sexual Intercourse with the Personification of Ayahuasca
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    30%
    Tryptamines
    Psilocybin
    30%
    Psilocin
    30%
    DMT
    30%
    5-MeO-DMT
    30%
    Phenethylamines
    Mescaline
    30%
    2C-B
    30%
    2C-E
    30%

    Effects Erowid Bluelight

    Aggregated from 141 Erowid and 25 Bluelight experience reports

    Positive Effects 48

    Empathy 61.7% 70%
    Color Enhancement 51.8% 84%
    Stimulation 50.4% 70%
    Music Enhancement 45.2% 90%
    Euphoria 41.6% 82%
    Introspection 41.0% 85%
    Tactile Enhancement 38.3% 70%
    Focus Enhancement 36.9% 70%
    Awe 36.0% 83%
    Geometric Imagery 36.0% 87%
    Closed-Eye Visuals 33.1% 88%
    Thought Acceleration 28.0% 80%
    Insight 20.0% 91%
    Revelatory Insight 20.0% 88%
    Body High 18.1% 82%
    Sedation 16.9% 80%
    Mystical Quality 16.0% 90%
    Joy 16.0% 84%
    Environmental Transfiguration 16.0% 85%
    Contentment 16.0% 78%

    Adverse Effects 34

    Nausea 66.3% 89%
    Anxiety 57.2% 87%
    Fear 36.0% 86%
    Vomiting 36.0% 91%
    Entity Imagery 28.0% 85%
    Dissociation 26.5% 85%
    Panic 20.0% 89%
    Body Load 20.0% 78%
    Motor Impairment 13.9% 85%
    Memory Suppression 12.8% 70%
    Dizziness 12.0% 85%
    Sweating 8.4% 82%
    Thought Deceleration 8.0% 80%
    Restlessness 8.0% 82%
    Body Temperature Change 8.0% 85%
    Pain Enhancement 8.0% 88%
    Paranoia 8.0% 90%
    Increased Heart Rate 5.7% 70%
    Headache 4.8% 80%
    Psychosis 4.3% 70%

    Combinations TripSit

    Trip Reports Effect Index

    My First Experience with Unity Josie My First Proper Psychedelic Experience Greg My Second Experience with Unity Josie Best Cake I've Had for a While Greg Trying to Engage in Sexual Intercourse with the Personification of Ayahuasca Greg I Was the Universe's Prophet Greg These Voices Are the Building Blocks of Consciousness Anonymous Reader
    Ayahuasca's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible