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    This substance involves MAOI activity. Dangerous interactions can occur with many common foods and medications. Research contraindications thoroughly.

    Ayahuasca Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 5 corroborating sources
    • descriptive-only dose data
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data

    Aliases: Aya, Cipó, Yage, Yaje, Brew, pharmahuasca

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Ayahuasca is a brew combining DMT-containing plants with MAOI-containing plants, requiring both components to produce psychoactive effects. Traditional brews vary widely in potency depending on plant sources, preparation methods, and regional practices. The purgative effects (nausea, vomiting, diarrhea) are considered an integral part of the traditional experience and can be intense.

    Dose Information TheDrug.Wiki PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Oral (Traditional B. Caapi + P. Viridis Brew) Smallcup(50-75mloftraditionalbrew) - Largecup(150-200mloftraditionalbrew) Multipleservingsorveryconcentratedbrew+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral (Syrian Rue + Mimosa Hostilis) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 5-10 hrs
    Oral (Syrian Rue + Acacia Confusa) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs
    Oral (Pharmahuasca - Extracted Alkaloids) 15-30 min 19-40 min 1-2 hrs 1-2 hrs 1-6 hrs 4-8 hrs
    Oral (Traditional B. Caapi + P. Viridis Brew) 19-60 min 30-60 min 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs
    Oral 18-60 min - 1-2 hrs 1-2 hrs 1-8 hrs 4-8 hrs

    Effect Profile

    166 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 141 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    internal hallucinations autonomous entity contact autonomous entities colour enhancement synesthesia drifting +7 more
    Headspace Depth ×3
    10
    conceptual thinking personal meaning enhancement thought connectivity emotional amplification and catharsis feelings of interdependent opposites subconscious communication +8 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations synesthesia
    Body Load / Somatic Effects ×1
    10
    nausea physical discomfort muscle tension
    Empathogen 9.1
    Intense+ 9/10

    Strong sensory enhancement, empathy, euphoria, and stimulation

    Empathy / Social Openness ×3
    9
    empathy
    Euphoria / Mood Elevation ×2
    9
    euphoria emotion enhancement
    Stimulation ×1
    9
    stimulation restlessness
    Sensory Enhancement ×1
    10
    enhanced tactile sensation spontaneous tactile sensations colour enhancement acuity enhancement
    Stimulant 6.6
    Strong+ 7/10

    Strong anxiety/jitters and focus with moderate stimulation and euphoria

    Stimulation / Energy ×3
    7
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria
    Focus / Productivity ×2
    9
    analysis enhancement thought acceleration
    Anxiety / Jitters ×1
    10
    restlessness muscle tension

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    30%
    Tryptamines
    Psilocin
    30%
    DMT
    30%
    5-MeO-DMT
    30%
    Phenethylamines
    Mescaline
    30%
    2C-B
    30%
    2C-E
    30%

    Effects Erowid Bluelight

    Aggregated from 141 Erowid and 25 Bluelight experience reports

    Positive Effects 48

    Empathy 61.7% 70%
    Color Enhancement 51.8% 84%
    Stimulation 50.4% 70%
    Music Enhancement 45.2% 90%
    Euphoria 41.6% 82%
    Introspection 41.0% 85%
    Tactile Enhancement 38.3% 70%
    Focus Enhancement 36.9% 70%
    Awe 36.0% 83%
    Geometric Imagery 36.0% 87%
    Closed-Eye Visuals 33.1% 88%
    Thought Acceleration 28.0% 80%
    Insight 20.0% 91%
    Revelatory Insight 20.0% 88%
    Body High 18.1% 82%
    Sedation 16.9% 80%
    Mystical Quality 16.0% 90%
    Joy 16.0% 84%
    Environmental Transfiguration 16.0% 85%
    Contentment 16.0% 78%

    Adverse Effects 34

    Nausea 66.3% 89%
    Anxiety 57.2% 87%
    Fear 36.0% 86%
    Vomiting 36.0% 91%
    Entity Imagery 28.0% 85%
    Dissociation 26.5% 85%
    Panic 20.0% 89%
    Body Load 20.0% 78%
    Motor Impairment 13.9% 85%
    Memory Suppression 12.8% 70%
    Dizziness 12.0% 85%
    Sweating 8.4% 82%
    Thought Deceleration 8.0% 80%
    Restlessness 8.0% 82%
    Body Temperature Change 8.0% 85%
    Pain Enhancement 8.0% 88%
    Paranoia 8.0% 90%
    Increased Heart Rate 5.7% 70%
    Headache 4.8% 80%
    Psychosis 4.3% 70%

    Combinations TripSit

    Cross-Check Ayahuasca with another substance

    Trip Reports Effect Index

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Reddit 8 reports 1 positive 7 neutral visit
    First time with medicine in Costa Rica positive r/Ayahuasca ▲7 2 comments

    WOW. I had the most amazing experience at a San Pedro retreat at Ananda Lodge in Costa Rica. Blown away by how held, cared for and authentic the owners and center is. Love how intimate the groups were.

    u/josieandthecats · 2026-04-29
    I thought ayahuasca would fix me… my experience as someone with OCD neutral r/Ayahuasca ▲45 28 comments

    I wanted to share this because I wish I had read something like this before I went into it. I came to ayahuasca from a place of desperation. At that time, I was already dealing with OCD—but it was mostly health anxiety.

    u/Bulky_Lawfulness_556 ★ 2 reports · 2026-04-28
    The real work was always in the integration, but I didn’t expect it to go that far neutral r/Ayahuasca ▲18 21 comments

    From the beginning, I knew that the real work with ayahuasca wasn’t the ceremony itself, but what comes after. The visions and intensity matter, of course, but they felt like openings, not conclusions. What I didn’t expect was how far that integration process would take me.

    u/Author_MarcHenri · 2026-05-04
    My ayahuasca experience neutral r/Ayahuasca ▲17 2 comments

    Ayahuasca was incredible—also unbelievably difficult and physically painful. At one point, I almost canceled my next ayahuasca trip to Peru because of how intense it was. But after the last ceremony, I was completely blown away and in awe.

    u/Optimal-Initiative-7 · 2026-04-28
    Returning to Soltara neutral r/Ayahuasca ▲10 7 comments

    I’m heading back to Soltara in Costa Rica for my second visit in the past year and a half. The first time I went I hadn’t worked with any plant medicine before. I was struggling in my life back then, I felt stuck and like I was leaking.

    u/Previous_Water_6194 · 2026-04-30
    Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
    The Din of Celestial Birds positive exp #90922

    I started my enchanting and beautiful affair with ayahuasca in Goa; which was to mark a very magical end to my sojourn in India. Visionary splendour, ceremonies and nocturnal visits to the realm of spirits. 5 days prior to the ceremonies, I visited a French shaman – A.

    Ithica
    My Spiritual Limbs Were Tied positive exp #58796

    An account of drinking the psychedelic tea Ayahuasca by a long time meditator and spiritual practitioner. My friendship with Robert began in the late 60’s. We shared a mutual interest in spirituality and, at that time, we had both experimented with psychedelic substances as a means of arriving at a deeper spiritual und...

    Kali · oral
    A Rookie's Bumbling Notes positive exp #101226

    Ayahuasca: a rookie's bumbling notes Among the myriad of vines that make the Amazon jungle their home, there is one with particularly unique properties. The name of that vine is Ayahuasca. When mixed with other Amazonian plants and shrubs into a tea and ingested, it is said to produce powerful hallucinogenic effects.

    Oswald Rabbit · 1 shot oral / 0.5 shots oral
    I'm behind the Underneath neutral exp #73580

    The Second Night (IMO) = In my opinion. I was a more apprehensive on this second night after having recorded the physical and emotional effects of last night, the fragmented stories of others experiences and my own to some degree: the physical payment of vomiting and bodily soreness wasn’t ‘it’, nor was it even the act...

    Unoanimo · 3.5 oz oral
    Allow Yourself to Be Devoured by the Alligator neutral exp #117847

    “Allow yourself to be devoured by the Alligator” On the 21-09-19 I attended an ayahuasca ceremony in Denmark. Here is a transcript of my diary covering the events. (Drafted on word starting on the 28-12-19. Originally written down in my diary 22-09-19).

    Simon C
    Pacha Mama neutral exp #116009

    My flight from L.A. to Lima was sooooo long! Eight hours with my mask AND face shield left me unrested and annoyed beyond belief! I arrived in Lima and had to wait in the airport for hours before my 4o’clock flight to Tarapoto. During the flight I could look down and see mighty rivers and the rainforest below.

    M. B.
    Long-Lasting Trauma cautionary exp #104149

    I warn you that this report is more than just a simple trip report. It covers many months as the impact of the trip didn’t stop after the active molecules had dispersed. I will try (as best as possible) to give a detailed account of what I went through with this powerful psychedelic. It all started around 5 years ago.

    Jhi-dou · 1 cup oral
    Wrestling With Time and Space cautionary exp #111866

    INTRO: I decided to try ayahuasca a long time ago, but now I can say with certainty that I’m very glad I didn’t have a chance to try it in my 20s. I believe this kind of ego-shattering experience requires a lot of mental sobriety and emotional maturity in order not to be confused for a psychotic episode.

    Jasenka · 1 cup oral / 1 cup oral
    Bluelight 8 threads 2 positive 5 neutral 1 cautionary visit
    Pharmahuasca The End Of Time Parties With Aliens And Endless Torture positive

    Harmala + DMT Extract (Experienced) - The End of Time Celebration and Endless Pain Me: Years of heavy psychedelic experiences coupled with about 100+ breakthrough DMT experiences, of which very few even provided a fraction of this experience.

    scraped 2026-03-14
    Ayahuasca In Ecuador neutral

    Ayahuasca in Ecuador Alright... so I know this cute Canadian chick who introduced me to the idea of trying Ayahuasca. So then I did it. WOW is all I have to fucking say.

    scraped 2026-03-14
    Ayahuasca Dose First Time When The Student Is Ready The Teacher Appears neutral

    original (Spanish) post: NSFW : El sábado pasado tuve la oportunidad de asistir a una "ceremonia" de ayahuasca en Mexicali B.C. Yo nunca había asistido a ningún evento de este tipo pero sí he leído al respecto, al no tener experiencia pues puedo ser fácilmente "tomado por los pelos" por así decirlo, tengo entendido que...

    scraped 2026-03-14
    Ayahuasca First Time Brought Into Being Peace X Piece neutral

    DMT (Ayahuasca) First time ~ Brought into Being, Peace x Piece 1 teaspoon Syrian Rue powder 11 grams Mimosa Hostilis root bark ½ bowl of weed Note: for those of you who haven’t already, you would due well to also read Spinal’s Ayahuasca report up at the top of trip reports. Our stories are very much intermingled.

    scraped 2026-03-14
    Introduction To Pharmahuasca And The Binge neutral

    @JackARoe Has been imploring me to start a blog about some of my trip reports that involve certain combinations/doses of psychedelics, and I'm currently scripting a website to host them on.

    scraped 2026-03-14
    Ayahuasca First Time Hellfire neutral

    Overview I have spent the past month digesting this experience, and I'll likely continue to process it for a long while to come. This was one of the toughest things I have ever lived through. Over the course of a weekend in Peru, the brew dowsed me repeatedly and without mercy in my own worst fears and memories.

    scraped 2026-03-14
    Ayahuasca 1 Glass First Experience Long Lasting Trauma cautionary

    I warn you that this TR is more than just a simple trip report. It covers many months as the impact of the trip didn’t stop after the active molecules had dispersed. I will try (as best as possible) to give a detailed account of what I went through with this powerful psychedelic. It all started around 5 years ago.

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big & Dandy Oral DMT thread (Ayahuasca/Pharmahuasca)

    If i brewed these two together would this make an Ayahuasca brew ? What would be the general dose for these two, anyone know the ratio of syrian rue to Mimosa hostilis is?

    Read full thread on Bluelight →

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