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    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Oxymorphone

    Aliases: Opana, Numorphan, Stop signs, stopsigns

    Depressant Opioid

    Summary PsychonautWiki

    Oxymorphone (also known by the brand name Opana) is a semi-synthetic opioid analgesic used in the management of moderate to severe pain, and is similar in structure to other opioids such as morphine and heroin. Oxymorphone was first developed in Germany in 1914and introduced to the American market in 1959. Unlike many other opioids, oxymorphone is almost devoid of antitussive properties.Oxymorphone is an important precursor to other opioids and opioid antagonists such as naloxone.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-30mg 30mg+
    Insufflated 2-4mg 4-8mg 8-15mg 15mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 20-45 min 30-60 min 1-2 hrs 2-4 hrs 6-6 hrs
    Insufflated 5-10 min 15-30 min 1-2 hrs 1-3 hrs 6-6 hrs
    Rectal 10-30 min 30-60 min 1.5-3 hrs 2-3 hrs 6-6 hrs

    Opioid MME Calculator

    ⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
    mg
    3.3 mg Oxymorphone
    ≈
    — mg Morphine

    ⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

    Effect Profile

    81 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 71 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 8.1
    Intense 8/10

    Strong euphoria, pain relief, and itching/nausea with moderate sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    10
    pain relief analgesia
    Sedation / Relaxation ×1
    7
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    10
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Oxymorphone
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Cross-Tolerances

    Opioids
    Morphine
    80%
    Heroin
    80%
    Oxycodone
    80%
    Fentanyl
    80%
    Codeine
    80%
    Tramadol
    80%
    Kratom
    80%
    Methadone
    80%

    Effects Erowid Bluelight

    Aggregated from 71 Erowid and 10 Bluelight experience reports

    Positive Effects 17

    Euphoria 56.8% 91%
    Sedation 29.6% 86%
    Empathy 29.6% 65%
    Contentment 20.0% 85%
    Relaxation 20.0% 85%
    Stimulation 19.7% 75%
    Pain Relief 17.3% 90%
    Anxiety Suppression 12.7% 70%
    Muscle Relaxation 10.0% 85%
    Visual Distortions 10.0% 70%
    Awe 10.0% 80%
    Bliss 10.0% 90%
    Joy 10.0% 80%
    Tactile Enhancement 9.9% 70%
    Body High 8.6% 83%
    Music Enhancement 6.1% 80%
    Focus Enhancement 5.6% 70%

    Adverse Effects 15

    Nausea 42.0% 80%
    Body Load 40.0% 80%
    Irritability 30.0% 80%
    Dizziness 20.0% 82%
    Vomiting 20.0% 95%
    Headache 14.8% 85%
    Stomach Cramps 10.0% 75%
    Tinnitus 10.0% 80%
    Motor Suppression 10.0% 75%
    Appetite Suppression 10.0% 70%
    Dysphoria 10.0% 80%
    Numbness 10.0% 90%
    Sweating 8.6% 85%
    Confusion 7.4% 75%
    Pupil Dilation 5.6% 70%

    Combinations TripSit

    Pill Identifiers

    9 known pill identifiers on record — view imprints, colors, shapes, and images
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    Oxymorphone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki