Summary
Oxymorphone (also known by the brand name Opana) is a semi-synthetic opioid analgesic used in the management of moderate to severe pain, and is similar in structure to other opioids such as morphine and heroin. Oxymorphone was first developed in Germany in 1914and introduced to the American market in 1959. Unlike many other opioids, oxymorphone is almost devoid of antitussive properties.Oxymorphone is an important precursor to other opioids and opioid antagonists such as naloxone.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 2-4mg | 4-6mg | - | 6-10mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 1-2 hrs | 2-4 hrs | 6 hrs |
| Insufflated | 5-10 min | 15-30 min | 1-2 hrs | 1-3 hrs | 6 hrs |
| Rectal | 10-30 min | 30-60 min | 1.5-3 hrs | 2-3 hrs | 6 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Physical Euphoria
- Pain Relief
- Analgesia
Negative
- Respiratory Depression
- Nausea
- Skin Flushing
- Dry Mouth
- Sedation
- Pupil Constriction
- Itchiness
- Difficulty Urinating
- Relaxant
Positive
- Cognitive Euphoria
- Dream Potentiation
- Anxiety Suppression
- Euphoria
- Mood lift
- Cognitive euphoria
- Anxiety suppression
Negative
- Constipation
- Compulsive Redosing
- Compulsive redosing
Positive
- Visual geometry
Negative
- Decreased Libido
- Appetite Suppression
- Orgasm Suppression
- Appetite suppression
- Spatial disorientation
- Dulled perception
- Internal hallucinations
- Internal hallucination
- Visual and auditory hallucinations